{"id":16,"date":"2026-06-18T17:25:30","date_gmt":"2026-06-18T09:25:30","guid":{"rendered":"http:\/\/127.0.0.1\/?post_type=product&#038;p=16"},"modified":"2026-07-22T14:31:39","modified_gmt":"2026-07-22T06:31:39","slug":"pr","status":"publish","type":"product","link":"https:\/\/suntay.cn\/index.php\/product\/pr\/","title":{"rendered":"[\u9510\u6258\u559c]\u785d\u9178\u7518\u6cb9\u8f6f\u818f"},"content":{"rendered":"<p>\u3010\u836f\u54c1\u540d\u79f0\u3011\u901a\u7528\u540d\u79f0:\u785d\u9178\u7518\u6cb9\u8f6f\u818f<\/p>\n<p>\u82f1\u6587\u540d\u79f0:Nitroglycerin Ointment<\/p>\n<p>\u6c49\u8bed\u62fc\u97f3:Xiaosuan Ganvou Ruangao<\/p>\n<p>\u3010\u6210\u00a0\u00a0\u00a0\u00a0\u4efd\u3011\u672c\u54c1\u6bcf\u514b\u542b\u4e3b\u8981\u6210\u4efd\u785d\u9178\u7518\u6cb92mg\uff0c\u8f85\u6599\u4e3a:\u767d\u51e1\u58eb\u6797\u3001\u7f8a\u6bdb\u8102\u3001\u4e73\u7cd6\u7b49\u3002<\/p>\n<p>\u672c\u54c1\u7684\u4e3b\u8981\u6210\u4efd\u4e3a\u785d\u9178\u7518\u6cb9\uff0c\u5176\u5316\u5b66\u540d\u79f0\u4e3a:\u7518\u6cb9\u4e09\u785d\u9178\u916f\u3002<\/p>\n<p>\u5206\u5b50\u91cf:227.09 \u5206\u5b50\u5f0f:C<sub>3<\/sub>H<sub>5<\/sub>N<sub>3<\/sub>O<sub>9<\/sub><\/p>\n<p>\u3010\u6027 \u00a0\u00a0\u00a0\u72b6\u3011\u672c\u54c1\u4e3a\u6cb9\u6027\u57fa\u8d28\u7684\u767d\u8272\u6216\u7c7b\u767d\u8272\u8f6f\u818f\u3002<\/p>\n<p>\u3010\u9002 \u5e94 \u75c7\u3011\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u809b\u88c2\u4e0e\u7f13\u89e3\u809b\u88c2\u5f15\u8d77\u7684\u75bc\u75db\u3002<\/p>\n<p>\u3010\u89c4 \u00a0\u00a0\u00a0\u683c\u30110.2%<\/p>\n<p>\u3010\u7528\u6cd5\u7528\u91cf\u3011\u6bcf\u65e53\u6b21\uff0c\u6bcf\u6b21\u6324\u51fa1-1.5cm\u818f\u4f53(\u53c2\u89c1\u5305\u88c5\u76d2\u4e0a\u7684\u523b\u5ea6)\uff0c\u7f6e\u4e8e\u6307\u7aef\uff0c\u7ecf\u809b\u95e8\u6d82\u4e8e\u809b\u7ba1\u5185(\u809b\u95e8\u5185\u7ea61cm)\uff0c\u6216\u9075\u533b\u5631\u3002\u6bcf\u6b21\u7528\u5b8c\u540e\u8bf7\u7acb\u523b\u62e7\u7d27\u7ba1\u76d6\u3002\u7528\u836f\u540e\u8bf7\u6d17\u624b\u3002<\/p>\n<p>\u3010\u4e0d\u826f\u53cd\u5e94\u3011\u5934\u75db\u662f\u6700\u5e38\u89c1\u7684\u53cd\u5e94\u3002\u7ecf\u5e38\u662f\u7f13\u548c\u7684\uff0c\u5e76\u4e14\u591a\u53d1\u751f\u4e8e\u5f00\u59cb\u7684\u51e0\u6b21\u5e94\u7528\u3002\u5c11\u6570\u7684\u75c5\u4eba\u5934\u75db\u4f1a\u6bd4\u8f83\u4e25\u91cd\u6216\u6301\u7eed\u3002\u5982\u679c\u5934\u75db\u6301\u7eed,\u5e94\u51cf\u5c11\u7528\u836f\u5242\u91cf(\u89c1\u836f\u7269\u8fc7\u91cf)\u3002\u5982\u679c\u5934\u75db\u7ee7\u7eed\u53d1\u751f\u6216\u6bd4\u8f83\u4e25\u91cd\uff0c\u5e94\u505c\u6b62\u6cbb\u7597\u3002<\/p>\n<p>\u672c\u54c1\u7684\u5176\u4ed6\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u8fd8\u5305\u62ec:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u5934\u6655;<\/li>\n<li>\u6076\u5fc3\u548c\u5455\u5410;<\/li>\n<li>\u76f4\u80a0\u51fa\u8840;<\/li>\n<li>\u75bc\u75db;<\/li>\n<li>\u809b\u7ba1\u7619\u75d2\u6216\u707c\u70ed\u611f;<\/li>\n<li>\u5fc3\u8df3\u52a0\u5feb;<\/li>\n<li>\u89c6\u529b\u6a21\u7cca;<\/li>\n<li>\u75b2\u52b3\u611f;<\/li>\n<li>\u76ae\u80a4\u8fc7\u654f\u53cd\u5e94;<\/li>\n<li>\u4f4e\u8840\u538b;<\/li>\n<li>\u6655\u53a5\uff1b<\/li>\n<li>\u5fc3\u7ede\u75db\u80f8\u75db\u52a0\u91cd;<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u4e0a\u8ff0\u6240\u5217\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u672a\u5305\u62ec\u672c\u54c1\u62a5\u9053\u7684\u6240\u6709\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<p>\u5927\u5c0f\u4fbf\u5931\u7981\u4e5f\u53ef\u80fd\u662f\u5176\u526f\u53cd\u5e94\uff0c\u867d\u7136\u5c1a\u672a\u89c1\u62a5\u9053\uff0c\u505c\u7528\u540e\u6b64\u79cd\u75c7\u72b6\u4f1a\u6d88\u5931\u3002<\/p>\n<p>\u7f55\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u80a0\u8815\u52a8\u51cf\u6162\u3002<\/p>\n<p>\u3010\u7981 \u00a0\u00a0\u00a0\u5fcc\u3011\u5982\u4e0b\u60a3\u8005\u5e94\u7981\u7528:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u5e74\u9f84\u5c0f\u4e8e18\u5c81;<\/li>\n<li>\u5df2\u77e5\u5bf9\u785d\u9178\u76d0\u7c7b\u836f\u7269\u8fc7\u654f;<\/li>\n<li>\u4f4e\u8840\u538b;<\/li>\n<li>\u4f53\u4f4d\u6027\u4f4e\u8840\u538b;<\/li>\n<li>\u4f4e\u8840\u5bb9\u91cf\u75c7\uff0c\u5982\u7531\u8131\u6c34\u6216\u5931\u8840\u5f15\u8d77;<\/li>\n<li>\u8111\u635f\u4f24;<\/li>\n<li>\u9885\u5185\u51fa\u8840(\u8111\u51fa\u8840);<\/li>\n<li>\u8111\u4f9b\u8840\u4e0d\u8db3;<\/li>\n<li>\u504f\u5934\u75db;<\/li>\n<li>\u590d\u53d1\u6027\u5934\u75db;<\/li>\n<li>\u5fc3\u8f93\u51fa\u4e3b\u52a8\u8109\u72ed\u7a84(\u4e3b\u52a8\u8109\u72ed\u7a84);<\/li>\n<li>\u5fc3\u810f\u74e3\u819c\u72ed\u7a84(\u4e8c\u5c16\u74e3\u72ed\u7a84);<\/li>\n<li>\u5fc3\u808c\u5f02\u5e38\u589e\u751f\u6027\u5fc3\u810f\u75be\u75c5(\u80a5\u5927\u6027\u6897\u585e\u578b\u5fc3\u808c\u75c5)\uff1b<\/li>\n<li>\u5fc3\u5305\u708e\uff0c\u9650\u5236\u5fc3\u810f\u6b63\u5e38\u8df3\u52a8(\u7f29\u7a84\u6027\u5fc3\u5305\u708e);<\/li>\n<li>\u5fc3\u5305\u79ef\u6db2\uff0c\u963b\u788d\u5fc3\u810f\u6b63\u5e38\u8df3\u52a8(\u5fc3\u5305\u586b\u585e);<\/li>\n<li>\u91cd\u5ea6\u8d2b\u8840;<\/li>\n<li>\u95ed\u89d2\u578b\u9752\u5149\u773c\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u5bf9\u672c\u54c1\u5176\u4ed6\u6210\u4efd\u8fc7\u654f\u8005\u5e94\u7981\u7528\u3002<\/p>\n<p>\u5982\u4e0b\u60a3\u8005\u5e94\u614e\u7528;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u4e25\u91cd\u809d\u810f\u75be\u75c5;<\/li>\n<li>\u4e25\u91cd\u80be\u810f\u75be\u75c5;<\/li>\n<li>\u5fc3\u7ede\u75db;<\/li>\n<li>\u5fc3\u529b\u8870\u7aed;<\/li>\n<li>\u8fd1\u671f\u51fa\u73b0\u5fc3\u810f\u4e8b\u4ef6\u60a3\u8005\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u3010\u6ce8\u610f\u4e8b\u9879\u30111.\u672c\u54c1\u4e3a\u5c40\u90e8\u7528\u836f\uff0c\u4e0d\u5f97\u53e3\u670d\u3002<\/p>\n<p>2.\u7528\u540e\u8bf7\u6d17\u624b\u3002<\/p>\n<p>3.\u7528\u836f\u671f\u95f4\u4ece\u5367\u4f4d\u6216\u5750\u4f4d\u7a81\u7136\u7ad9\u8d77\u987b\u8c28\u614e\uff0c\u4ee5\u514d\u7a81\u53d1\u4f53\u4f4d\u6027\u964d\u538b\u3002<\/p>\n<p>4.\u907f\u514d\u63a5\u89e6\u773c\u775b\u548c\u5176\u4ed6\u9ecf\u819c(\u5982\u53e3\u3001\u9f3b\u7b49)\u3002<\/p>\n<p>5.\u4ea4\u53c9\u8fc7\u654f\u53cd\u5e94\uff0c\u5bf9\u5176\u4ed6\u785d\u9178\u916f\u6216\u4e9a\u785d\u9178\u916f\u8fc7\u654f\u60a3\u8005\u4e5f\u53ef\u80fd\u5bf9\u672c\u54c1\u8fc7\u654f\uff0c\u4f46\u5c5e\u7f55\u89c1\u3002<\/p>\n<p>6.\u672c\u54c1\u6027\u72b6\u53d1\u751f\u53d8\u5316\u65f6\u7981\u6b62\u4f7f\u7528\u3002<\/p>\n<p>7.\u8bf7\u5c06\u672c\u54c1\u653e\u5728\u513f\u7ae5\u4e0d\u80fd\u63a5\u89e6\u7684\u5730\u65b9\u3002<\/p>\n<p>8.\u5982\u6b63\u5728\u4f7f\u7528\u5176\u4ed6\u836f\u54c1\uff0c\u5305\u62ec\u6cbb\u7597\u80f8\u75db\u548c\u5176\u4ed6\u5fc3\u810f\u75c5\u836f\u7269\uff0c\u4f7f\u7528\u672c\u54c1\u524d\u8bf7\u54a8\u8be2\u533b\u5e08\u6216\u836f\u5e08\uff0c\u8be6\u60c5\u8bf7\u53c2\u89c1\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011\u9879\u3002<\/p>\n<p>9.\u90e8\u5206\u60a3\u8005\u4f7f\u7528\u672c\u54c1\uff0c\u5c24\u5176\u662f\u9996\u6b21\u4f7f\u7528\uff0c\u53ef\u80fd\u5bfc\u81f4\u5934\u6655\u3001\u5934\u91cd\u3001\u89c6\u529b\u6a21\u7cca\u3001\u5934\u75db\u6216\u75b2\u52b3\uff0c\u9a7e\u9a76\u5458\u6216\u673a\u5668\u64cd\u4f5c\u4eba\u5458\u614e\u7528\u3002<\/p>\n<p>\u3010\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\u3011\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u614e\u7528\u3002<\/p>\n<p>\u3010\u513f\u7ae5\u7528\u836f\u3011\u5e74\u9f84\u5c0f\u4e8e18\u5c81\u7684\u513f\u7ae5\u5e94\u7981\u7528\u3002<\/p>\n<p>\u3010\u8001\u5e74\u7528\u836f\u3011\u5c1a\u65e0\u8001\u5e74\u60a3\u8005\u7528\u836f\u7684\u5177\u4f53\u62a5\u9053\u3002<\/p>\n<p>\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011\u5982\u4e0e\u5176\u4ed6\u836f\u7269\u540c\u65f6\u5e94\u7528\u6216\u8fd1\u671f\u60a3\u8005\u66fe\u7ecf\u670d\u7528\u5176\u4ed6\u836f\u7269\uff0c\u5305\u62ec\u975e\u5904\u65b9\u836f\uff0c\u53ef\u80fd\u4f1a\u53d1\u751f\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u8be6\u60c5\u8bf7\u54a8\u8be2\u533b\u5e08\u6216\u836f\u5e08\uff0c\u4ee5\u786e\u8ba4\u5408\u5e76\u7528\u836f\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p>\u5f53\u5e94\u7528\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u65f6\uff0c\u4e0d\u5f97\u540c\u65f6\u670d\u7528\u4e0b\u5217\u836f\u7269\u3002\u7531\u4e8e\u4e0e\u8fd9\u4e9b\u836f\u7269\u5408\u7528\u53ef\u80fd\u4f1a\u4f7f\u8840\u538b\u663e\u8457\u4e0b\u964d\uff0c\u5bfc\u81f4\u60a3\u8005\u51fa\u73b0\u5934\u6655\u3001\u6655\u53a5\uff0c\u751a\u81f3\u53d1\u751f\u5fc3\u810f\u4e8b\u4ef6\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u67b8\u6a7c\u9178\u897f\u5730\u90a3\u975e(Viagra);<\/li>\n<li>\u4ed6\u8fbe\u62c9\u975e(Cialis);<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u4f10\u5730\u90a3\u975e(Levitra);<\/li>\n<li>\u5355\u785d\u9178\u5f02\u5c71\u68a8\u916f;<\/li>\n<li>\u4e9a\u785d\u9178\u5f02\u620a\u916f\u3002<\/li>\n<li>\u785d\u9178\u7518\u6cb9\u7528\u4e8e\u5fc3\u7ede\u75db\u6216\u5fc3\u529b\u8912;<\/li>\n<li>\u785d\u9178\u5f02\u5c71\u68a8\u916f;<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u7531\u4e8e\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u53ef\u5f15\u8d77\u8840\u538b\u964d\u4f4e\uff0c\u5f53\u60a3\u8005\u540c\u65f6\u670d\u7528\u5176\u4ed6\u964d\u538b\u836f\u7269\u65f6\uff0c\u964d\u538b\u4f5c\u7528\u53ef\u80fd\u88ab\u52a0\u5f3a\u3002\u8fd9\u79cd\u5408\u5e76\u7528\u836f\u53ef\u80fd\u5bfc\u81f4\u5934\u6655\u3002\u5176\u4ed6\u964d\u538b\u836f\u7269\u5305\u62ec:<\/p>\n<ul>\n<li>\u6297\u9ad8\u8840\u538b\u836f\u7269\uff0c\u5982\u03b2-\u53d7\u4f53\u963b\u6ede\u5242\u3001ACE\u6291\u5236\u5242\u3001a-\u53d7\u4f53\u963b\u6ede\u5242\u3001\u5229\u5c3f\u5242\u3001\u9499\u901a\u9053\u963b\u6ede\u5242;<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u4e09\u73af\u7c7b\u6297\u6291\u90c1\u836f\uff0c\u5982\u963f\u7c73\u66ff\u6797;<\/li>\n<li>MAOI\u6297\u6291\u90c1\u836f\uff0c\u5982\u82ef\u4e59\u80bc;<\/li>\n<li>\u5e38\u7528\u6297\u7cbe\u795e\u75c5\u836f\uff1b<\/li>\n<li>\u4e59\u9187\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u5176\u4ed6\u836f\u7269:<\/p>\n<ul>\n<li>\u4e59\u9170\u534a\u80f1\u6c28\u9178\u53ef\u80fd\u589e\u5f3a\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u5bf9\u8840\u6d41\u7684\u4f5c\u7528;<\/li>\n<li>\u4e0e\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u5408\u7528\u65f6\uff0c\u809d\u7d20\u7684\u7597\u6548\u53ef\u80fd\u51cf\u5f31\uff1b<\/li>\n<li>\u4e0e\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u540c\u65f6\u5e94\u7528\u65f6\uff0c\u963f\u66ff\u666e\u9176\u7684\u7597\u6548\u53ef\u80fd\u51cf\u5f31\uff1b<\/li>\n<li>\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u4e0e\u53cc\u6c22\u9ea6\u89d2\u80fa\u5408\u7528\uff0c\u53ef\u80fd\u589e\u5f3a\u53cc\u6c22\u9ea6\u89d2\u80fa\u7684\u6d3b\u6027\uff0c\u5bfc\u81f4\u51a0\u72b6\u8840\u7ba1\u6536\u7f29;<\/li>\n<li>\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u548c\u975e\u753e\u4f53\u6297\u708e\u836f\u53ef\u80fd\u964d\u4f4e\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u7684\u7597\u6548\u3002<\/li>\n<\/ul>\n<p>\u3010\u836f\u7269\u8fc7\u91cf\u3011\u5934\u75db\u3001\u89c6\u89c9\u6a21\u7cca\u548c\u5934\u6655\u662f\u836f\u7269\u8fc7\u91cf\u7684\u4e3b\u8981\u75c7\u72b6\u3002\u5f53\u53d1\u73b0\u6709\u8fd9\u4e9b\u75c7\u72b6\u5e94\u8be5\u6682\u505c\u7528\u836f\u81f3\u5c118\u5c0f\u65f6\uff0c\u968f\u540e\u7ed9\u836f\u5242\u91cf\u51cf\u534a\u3002<\/p>\n<p>\u5934\u75db\u53ef\u4ee5\u7528\u7684\u4e00\u822c\u6b62\u75db\u836f\u5982\u6251\u70ed\u606f\u75db\u7b49\u6cbb\u7597\u3002\u5982\u679c\u5934\u75db\u5267\u70c8\u6216\u6301\u4e45\uff0c\u5e94\u7acb\u5373\u505c\u836f\u5e76\u4e0e\u533b\u5e08\u8054\u7cfb\u3002<\/p>\n<p>\u3010\u4e34\u5e8a\u8bd5\u9a8c\u3011\u6309\u7167GCP\u7684\u8981\u6c42\u5728\u5168\u56fd7\u4e2a\u7814\u7a76\u4e2d\u5fc3\u968f\u673a\u5165\u9009240\u4f8b\u6027\u809b\u88c2\u60a3\u8005\uff0c\u8fdb\u884c\u4e3a\u671f2\u4e2a\u6708\u7597\u7a0b\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5e73\u884c\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff0c\u4e3b\u8981\u89c2\u5bdf\u6307\u6807\u4e3a\u809b\u88c2\u6108\u5408\u7387\u3001\u809b\u88c2\u76f8\u5173\u75bc\u75db\u7684\u7f13\u89e3\uff0c\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a:<\/p>\n<p>\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u785d\u9178\u7518\u6cb9\u7ec4\u6108\u5408\u738778.9%(N=114)\uff0c\u5b89\u6170\u5242\u7ec4\u6108\u5408\u738729.0%(N=107),\u809b\u88c2\u6108\u5408\u7387\u785d\u9178\u7518\u6cb9\u7ec4\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4(P&lt;0.05)\u3002\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u809b\u88c2\u75bc\u75db\u8bc4\u5206\uff0c\u785d\u9178\u7518\u6cb9\u7ec4\u4e0b\u964d\u4e8694.7%(N=114)\uff0c\u5b89\u6170\u5242\u7ec4\u4e0b\u964d\u4e8662.4%(N=107);\u809b\u88c2\u75bc\u75db\u7f13\u89e3\u785d\u9178\u7518\u6cb9\u7ec4\u660e\u663e\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4(P&lt;0.05)\u3002<\/p>\n<p>\u4e3b\u8981\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u8f7b\u5ea6\u7684\u5934\u75db\u3001\u5934\u80c0\uff0c\u53ef\u81ea\u884c\u7f13\u89e3\u6216\u53e3\u670d\u89e3\u70ed\u9547\u75db\u7247\u7f13\u89e3\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u8bba:\u5c40\u90e8\u5e94\u7528\u785d\u9178\u7518\u6cb9\u8f6f\u818f\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u7f13\u89e3\u809b\u88c2\u75bc\u75db;\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4fc3\u8fdb\u5408\uff0c\u63d0\u9ad8\u6cbb\u6108\u7387;\u7528\u4e8e\u809b\u88c2\u6cbb\u7597\u662f\u5b89\u5168\u7684\u3001\u53ef\u8010\u53d7\u7684\u3002<\/p>\n<p>\u3010\u836f\u7406\u6bd2\u7406\u3011\u785d\u9178\u7518\u6cb9\u5728\u5e73\u6ed1\u808c\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u5185\u4ee3\u8c22\u91ca\u653e\u51faNO\u3002NO\u4f5c\u4e3a\u5185\u76ae\u8212\u5f20\u56e0\u5b50\uff0c\u5176\u5728\u5e73\u6ed1\u808c\u7ec6\u80de\u5185\u6fc0\u6d3b\u9e1f\u82f7\u9178\u73af\u5316\u9176\uff0c\u589e\u52a0\u7ec6\u80de\u5185cGMP\u7684\u542b\u91cf\uff0c\u4ece\u800c\u6fc0\u6d3b\u4f9d\u8d56\u4e8ecGMP\u7684\u86cb\u767d\u6fc0\u9176\uff0c\u4fc3\u4f7f\u808c\u7403\u86cb\u767d\u8f7b\u94fe\u53bb\u78f7\u9178\u5316\uff0c\u4ece\u800c\u677e\u5f1b\u5e73\u6ed1\u808c\u3002<\/p>\n<p>\u809b\u7ba1\u5c40\u90e8\u5e94\u7528\u785d\u9178\u7518\u6cb9\uff0c\u53ef\u4ee5\u677e\u5f1b\u809b\u7ba1\u62ec\u7ea6\u808c\uff0c\u7f13\u89e3\u75c9\u631b\uff0c\u51cf\u8f7b\u75c7\u72b6;\u677e\u5f1b\u8840\u7ba1\u5e73\u6ed1\u808c\uff0c\u8212\u5f20\u8840\u7ba1\uff0c\u589e\u52a0\u8840\u7ba1\u5c40\u90e8\u7684\u8840\u4f9b\uff0c\u4fc3\u8fdb\u6e83\u75a1\u7684\u6108\u5408\u3002<\/p>\n<p>\u3010\u836f\u4ee3\u52a8\u529b\u5b66\u3011\u785d\u9178\u7518\u6cb9\u5728\u4f53\u5185\u5e7f\u6cdb\u4ee3\u8c22\uff0c\u820c\u4e0b\u7ed9\u836f\u5438\u6536\u8fc5\u901f\uff0c\u5176\u534a\u8870\u671f\u7ea6\u4e3a2~8min\u3002\u785d\u9178\u7518\u6cb9\u5728\u4f53\u5185\u4ee3\u8c22\u4e3a\u6d3b\u6027\u76841,2-\u4e8c\u785d\u9178\u7518\u6cb9\u916f\u548c1,3-\u4e8c\u785d\u9178\u7518\u6cb9\u916f\uff0c\u8fd9\u4e24\u79cd\u4ea7\u7269\u8fdb\u4e00\u6b65\u4ee3\u8c22\u4e3a1-\u785d\u9178\u7518\u6cb9\u916f\u548c2-\u785d\u9178\u7518\u6cb9\u916f\uff0c\u6700\u540e\u964d\u89e3\u4e3a\u7518\u6cb9\uff0c\u7518\u6cb9\u8fdb\u5165\u7cd6\u9175\u89e3\u9014\u5f84\u3002\u785d\u9178\u7518\u6cb9\u4e3b\u8981\u4ee5\u53bb\u785d\u57fa\u4ee3\u8c22\u4ea7\u7269\u7684\u8461\u8404\u7cd6\u919b\u9178\u884c\u751f\u7269\u5f62\u5f0f\uff0c\u7ecf\u80be\u810f\u6392\u6cc4\u3002<\/p>\n<p>\u672c\u54c1\u6309\u7167GCP\u7684\u8981\u6c42\u5bf9\u5065\u5eb7\u53d7\u8bd5\u8005\u8fdb\u884c\u4e86\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u8bd5\u9a8c\u300214\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u5206\u4e3a\u4e24\u7ec4\uff0c\u5206\u522b\u4e3a10\u4f8b\u548c4\u4f8b\u300210\u4f8b\u53d7\u8bd5\u8005\u809b\u5468\u6d82\u5e03\u785d\u9178\u7518\u6cb9\u8f6f\u818f\uff0c4\u4f8b\u53d7\u8bd5\u8005\u820c\u4e0b\u542b\u670d\u785d\u9178\u7518\u6cb9\u7247\u300210\u540d\u53d7\u8bd5\u8005\u809b\u5468\u6d82\u5e03\u785d\u9178\u7518\u6cb9\u8f6f\u818f(\u76f8\u5f53\u4e8e\u785d\u9178\u7518\u6cb90.75 mg)\u540e\uff0c\u4f53\u5185\u5438\u6536\u4e0d\u89c4\u5219\uff0c\u4ec5\u6709\u5c11\u91cf\u5438\u6536\uff0c\u8840\u836f\u6d53\u5ea6\u8f83\u4f4e\u30024\u540d\u53d7\u8bd5\u8005\u542b\u670d\u785d\u9178\u7518\u6cb9\u7247(\u76f8\u5f53\u4e8e\u785d\u9178\u7518\u6cb90.5 mg)\u540e\uff0c\u4f53\u5185\u5438\u6536\u8fc5\u901f\u3002<\/p>\n<p>\u6839\u636e\u6240\u5f97\u6570\u636e\u8ba1\u7b97\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u5982\u4e0b\u8868\u6240\u793a:<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"78\">&nbsp;<\/td>\n<td width=\"192\">\u785d\u9178\u7518\u6cb9\u8f6f\u818f\u7ec4\uff08\u809b\u5468\u6d82\u5e03\uff09<\/td>\n<td width=\"192\">\u785d\u9178\u7518\u6cb9\u7247\uff08\u53e3\u542b\uff09<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">t<sub>max<\/sub><\/td>\n<td width=\"192\">7.3\u00b12.3 min<\/td>\n<td width=\"192\">2.5\u00b10.6 min<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">C<sub>max<\/sub><\/td>\n<td width=\"192\">126\u00b151 ng\/L<\/td>\n<td width=\"192\">827\u00b1681 ng\/L<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">T<sub>1<\/sub><sub>\/<\/sub><sub>2<\/sub><\/td>\n<td width=\"192\">20.0\u00b111.4 min<\/td>\n<td width=\"192\">2.3\u00b11.3 min<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">Vd\/F<\/td>\n<td width=\"192\">7104\u00b13236 L<\/td>\n<td width=\"192\">8711\u00b15246 L<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">CL\/F<\/td>\n<td width=\"192\">331\u00b1228 L\u00b7min<sup>-1<\/sup><\/td>\n<td width=\"192\">2905\u00b12276 L\u00b7min<sup>-1<\/sup><\/td>\n<\/tr>\n<tr>\n<td width=\"78\">MRT(0-t)<\/td>\n<td width=\"192\">17.0\u00b16.6 min<\/td>\n<td width=\"192\">4.1\u00b11.1 min<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">AUC<sub>0<\/sub><sub>-t<\/sub><\/td>\n<td width=\"192\">2080\u00b1818 ng\/L\u00b7min<\/td>\n<td width=\"192\">2905\u00b12276 ng\/L\u00b7min<\/td>\n<\/tr>\n<tr>\n<td width=\"78\">AUC<sub>0<\/sub><sub>-\u221e<\/sub><\/td>\n<td width=\"192\">2958\u00b11331 ng\/L\u00b7min<\/td>\n<td width=\"192\">3010\u00b12318 ng\/L\u00b7min<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u76f8\u5bf9\u4e8e\u820c\u4e0b\u7ed9\u836f\u9014\u5f84\uff0c\u809b\u5468\u6d82\u5e03\u7ed9\u836f\u8840\u836f\u6d53\u5ea6\u8fbe\u5cf0(2.92:1)\uff0c\u5cf0\u503c\u6d53\u5ea6\u4f4e(0.1:1)\uff0c\u6d88\u9664\u534a\u8870\u671f(8.7:1)\u548c\u4f53\u5185\u6ede\u7559\u65f6\u95f4\u957f(4.1:1)\uff0c\u4f53\u5185\u5438\u6536\u91cf\u5c11(0.48:1)\u3002\u7ed9\u836f\u540e\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5206\u522b\u4e3a:\u820c\u4e0b75%; \u6d82\u5e0330%\uff0c\u5747\u4e3a\u8f7b\u5fae\u3001\u4e00\u8fc7\u6027\u3002\u4e0a\u8ff0\u6570\u636e\u53ef\u4ee5\u8ba4\u4e3a\u8be5\u79cd\u7ed9\u836f\u65b9\u5f0f\u8f83\u820c\u4e0b\u7ed9\u836f\u66f4\u5177\u5b89\u5168\u6027\u3002<\/p>\n<p>\u3010\u8d2e\u00a0\u00a0\u00a0\u00a0\u85cf\u3011\u907f\u5149\uff0c\u5bc6\u95ed\uff0c\u572825\u00b0C\u4ee5\u4e0b\u4fdd\u5b58\u3002<\/p>\n<p>\u3010\u5305\u00a0\u00a0\u00a0\u00a0\u88c5\u3011\u94dd\u7ba1\u5305\u88c5\uff0c10g\/\u652f\/\u76d2; 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